Under what condition would a driver taking antidepressants be disqualified?

A driver taking antidepressants would be disqualified under the condition of reporting persistent side effects because this indicates that the medication may be impairing their ability to safely operate a commercial vehicle. Persistent side effects could include drowsiness, blurred vision, or other cognitive impairments that could compromise the driver’s ability to perform their responsibilities on the road safely. The safety of the driver, as well as that of the passengers and the public, is of utmost importance.

The other options present considerations but do not inherently warrant disqualification. A history of depression doesn’t automatically disqualify someone; it's the management of their condition that matters. Not following a doctor’s prescription raises concerns about adherence to treatment but isn't a blanket disqualifier unless it leads to dangerous side effects. Lastly, having a medication prescribed by a general practitioner is standard and does not diminish its validity or safety. The critical factor is whether the individual can operate a vehicle safely while taking the medication and how they respond to it in practical terms.